hrp0086p1-p908 | Thyroid P1 | ESPE2016

Thyroid Function Anomalies in Children with Down Syndrome: Early TSH Alteration can Predict Future Hypothyroidism Development?

Mellia Jessica , Ottaviano Giorgio , Deiana Manuela , Marinoni Maddalena , Ragazzo Maria , Salvatoni Alessandro

Background: Subclinical hypothyroidism is a common finding in Down syndrome (DS) patients and transition towards overt hypothyroidism can occur, but there are no predictor factors to identify patients that will need replacement therapy later in life.Objective and hypotheses: This is a retrospective cohort study on a population of DS paediatric patients. This study was designed to evaluate possible early predictive features of hypothyroidism development.<...